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Prevention of Osteoporosis & Tooth decay by IP-6 + Inositol
Inasmuch as soft drinks are extremely popular beverages throughout the world, they are also a common cause of dental erosion and tooth decay, the acidity of the beverages being the primary factor in bringing about this destruction. The accompanying figure shows titratable acidity which is correlated with the loss of dental tissue by various soft drinks and the remarkable protective effect of IP-6 (in amber). In osteoporosis, there is excessive activity of bone-destroying osteoclast cells with concomitant inactivity of bone-forming osteoblast cells. Experiments show that IP-6 & inositol can modulate the behavior of these bone-forming and bone-destroying cells to prevent osteoporosis. Correlating with this laboratory observation, a recent population-study, conducted in Spain and published in the Journal of Medicinal Food (December 2008) reports that "Phytate [IP-6] consumption had a protective effect against osteoporosis.."; thus IP-6 deficient diet may be a risk factor for osteoporosis.
Radiation Protection by IP-6 & Inositol
The 2007 Centennial Meeting of The American Association for Cancer Research on Translational Medicine was held in Singapore 4-8 November 2007. A paper presented by Shamsuddin and colleagues showed that IP-6 and inositol protect human cells against radiation damage in the laboratory (in vitro) in various ways. For example while irradiation caused increased cell death (loss of cell attachment, apoptosis and necrosis) IP-6 and inositol treatment prevented cell death, in vitro. In vivo (in laboratory mice) either oral or topically administered IP-6 + Inositol significantly reduced the incidence and multiplicity of UV-induced skin tumors in mice. These data therefore suggest that IP-6 + inositol could help protect us from various forms of radiation damage such as UV from sun-exposure, radiation therapy, cosmic radiation, accidental or induced nuclear blasts etc.
IP-6 Acts Synergistically with Standard Chemotherapeutic Agents
Dr. Kawanishi and colleagues from Mie University, Japan report in the 2005 Nov-Dec issue of the journal Antioxid Redox Signal (Volume 7 pages:1728-1739) that while many anti-oxidants may be even harmful in cancer ("double-edged sword"), IP-6 is not only safe, but also beneficial; "...can safely protect humans against cancer" state the authors.
Reporting in the journal Breast Cancer Reserch & Treatment [vol. 79, pages 301-312, 2003], Dr. Tantivejkul and her co-authors report that in the laboratory IP-6 was effective against cancer cell lines that were either adriamycin resistant or ER (estrogen receptor) negative. Furthermore, IP-6 enhances the anticancer function of adriamycin or tamoxifen against human breast cancer cell lines.
Novel IP-6 Citrate Compounds
By combining the ever so common and useful citric acid with IP-6, a group of novel compounds with at least one citrate molecule attached at the hydroxyl group of the citric acid to the phosphate of the IP-6 molecule have been formulated (named IP-6c). Non-ruminants such as poultry, pigs and human can not utilize the phosphorous in dietary IP-6 resulting in not only decreased bone phosphorous, but also its excretion in water causing environmental contamination and eutrophication [Abelson PH: SCIENCE. vol 283, page 2015, 26 March 1999]. It has been demonstrated that addition of citric acid to the feed may improve IP-6 phosphorous utilization and increased bone phosphorous in poultry (Rafacz-Livingston et al, POULTRY SCIENCE, September 2005, vol 84 pages 1370-1375). Thus addition of IP-6c to animal feed may solve atleast in part, these dual problems: the chickens will be healthier and so as our environment! By virtue of IP-6c having more free binding sites to chelate cations (upto 24 sites in IP-6 hexacitrate, as opposed to 12 in IP-6) the novel compounds may be the most potent anti-oxidants to date [US Patent #7,009,067; additonal patents pending].
IP-6 Research Inc.
15 Charles Plaza, Suite 2508
Baltimore, MD 21201-3931
410-659-3906 phone
research@ip-6.net
© 2008 IP-6 Research Inc.. All rights reserved.
15 Charles Plaza, Suite 2508
Baltimore, MD 21201-3931
410-659-3906 phone
research@ip-6.net
© 2008 IP-6 Research Inc.. All rights reserved.