IP-6 Research Inc.

The Many Functions of IP-6 & Inositol

The Latest Research.......

Prostate Cancer, AIDS neoplastic Kaposi's Sarcoma and Leukemia

Androgen-independent prostate cancer are harder to treat. Dr. J.S. Diallo et al from Centre de recherche du Centre hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal, report in the October 2008 issue of the British Journal of Cancer, that there is "[E]nhanced killing of androgen-independent prostate cancer cells when IP-6 is combined with proteasome inhibitors". Dr. H.C. Tran and colleagues at the University of Maryland Biotechnology Institute and the School of Medicine in Baltimore report at the 94th Annual Meeting of the American Association for Cancer Research in Washington D.C. [July 11-14, 2003], that IP-6 blocks the tumorigenesis and angiogenic potential in both AIDS/Iatrogenic-related Kaposi's sarcoma and adult T-cell lymphoma cells in vitro [Proceeding of the American Association for Cancer Research Vol 44, March 2003, pages 577-578, Abstract #2536]. Professor Giorgio Lambertenghi Deliliers and his collagues from the University of Milan, Italy, report in the June 2002 issue of the British Journal of Haematology [vol. 117: pages 577-587] that IP-6 caused a dose-dependent cytotoxicity on various human myeloid leukemia cell lines as well as on fresh chronic myeloid leukemia (CML) progenitor cells; IP-6 however had no toxic effect on normal human hematopoetic cells (as is commonly seen after standard chemotherapeutic agents. The authors conclude "...the spectrum of neoplasia on which IP6 has antiproliferative activity could be extended to acute and chronic myeloid leukaemias".

IP-6 + Inositol Against Diabetes

Experiments with isolated murine pancreatic beta cells have shown that IP-6 stimulates these cells to secrete insulin" [Hoy et al, Journal of Biological Chemistry Vol: 278 #37 pages 35168-35171, September 12, 2003]. And Dilworth and colleagues report that IP-6 supplementation when administered in diet lowered blood glucose levels in rats. That diabetics could be benefited from IP-6 + Inositol is further supported by data from Nascimento and colleagues who report in the January 3, 2006 issue of the PNAS that in their experimental model, inositol itself may work as an antioxidant and not only prevents but also reverses many of the complications of diabetes. Thus, on one hand, IP-6 causes direct stimulation of insulin from pancreatic beta cells and inositol on the other hand helps in the prevention of complications of diabetes; combination of IP-6 + Inositol gives dual benefits.

Protection Against Radiation by IP-6 & Inositol

Radiation is energy distributed across the electromagnetic spectrum. Approximately 80% of all radiation encountered normally by mammals is from naturally-occurring sources. Radiation, particularly ionizing radiation, has an adverse effect on cells and tissues, primarily through cytotoxic effects. In humans, exposure to ionizing radiation occurs primarily through therapeutic techniques such as anticancer radiotherapy, through occupational and/or environmental exposure to human-derived radiation sources, or through occupational exposure to naturally-occurring radiation sources as in the case of aircraft flight personnel. And of course there is always the potential of war-time, accidental or terrorist-induced nuclear blast. One of the chronic or late effects of radiation-damage is cancer; the common non-melanoma skin cancer from sun-exposure is attributed to UV radiation. A report in the journal RADIATION PROTECTION DOSIMETRY (E-publication ahead of print 12 July 2007) by D. Cebrian and colleagues from the Radiobiology Laboratory of the Department of Environment, CIEMAT, Madrid, Spain, show a strong affinity of inositol hexaphosphate (IP-6) for uranium, suggesting that it could be an effective chelating agent for uranium in vivo. Data were presented at the 2007 Centennial Meeting of The American Association for Cancer Research on Translational Medicine in Singapore 4-8 November 2007 showing that either oral or topically administered IP-6 + Inositol significantly reduced the incidence and multiplicity of UV-induced skin tumors in mice (please go to "News" page).

DNA Repair, Kidney Stone Prevention - A Vitamin?!

Transcription of DNA to messenger RNA (mRNA) in eukaryotic cells is performed in the nucleus, and the mRNA is exported from the nucleus to the cytoplasm. Dr. John D. York and his collaborators from Duke University and Washington University School of Medicine report in 2 July 1999 issue of the journal SCIENCE [Vol. 285, pages 96-100] that the generation of IP-6 is required for proper and efficient nuclear export of mRNA to the cytoplasm. This study indicates that such export of mRNA may be in response to signaling mediated by IP-6. Thus incresed intracellular IP-6 may enhance nuclear export of mRNA. "..these studies constitute a signaling pathway from phosphatidylinositol 4,5 bisphosphate to inositol hexakisphosphate (IP6)." In a more recent paper [SCIENCE September 02, 2005, Volume 309, page: 1536], Macbeth et al from the Howards Hughes Medical Institute at the University of Utah report that IP-6 is essential for RNA editing. Drs. Y. MA and M.R. Lieber from the University of Southern California,Los Angeles, report in March 29, 2002 issue of the Journal of Biological Chemistry (Vol 277: pages 10756-9) that IP-6 is crucial in repair of DNA damage. DNA damage is not only the first step in cancer formation, but also is one of the earliest events following exposure to radiation. Thus IP-6 could be a radiation-protection agent. Indeed, a recent workshop [in Cambridge, Massachusetts February 16-17, 2005] by the US Department of Energy has explored the potential of IP-6 and other Inositol derivatives in human protection in the event of mass exposure to radiation. Professor Felix Grases and his co-workers have not only found IP-6 in human plasma and urine, but that the levels decreased on an IP-6 deficient-diet and restored quickly after taking a supplement, or after 2 weeks on an IP-6 sufficient-diet. Together with the numerous health benefits, these data strongly suggest that IP-6 could very well be a vitamin! They have shown that IP-6 prevents kidney stone formation; and more recently they also reported that IP-6 prevents cardiovascular calcification. Abnormal or pathological calcification of soft tissues such as blood vessels, heart etc. can have serious consequences insofar as atherosclerosis and myocardial infarction are concerned. Thus, preventing pathological calcification in the body will reduce the risk of cardiovascular disease, not to mention the excrutiating pain associated with kidney stone.

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