Molecular science. Published evidence.
Molecular mechanisms, experimental findings, and human studies. Explore the science of IP6 and inositol.
Figure 1. Inositol hexaphosphate, C6H18O24P6: six phosphate groups bonded to a six-carbon inositol ring.
New to the subject? Read these four chapters in order. Each one opens a page of the collection.
A phosphate-rich molecule found in cereal grains, legumes, and seeds, and present in human cells.
Read the molecular scienceCell cultures, animal experiments, and human studies each answer a different kind of question.
Learn how to read a studyFindings across cancer biology, immunology, metabolism, and neuroscience, with their limits.
Browse the research areasExperiments started at the University of Maryland School of Medicine in 1985.
Meet the scientistIron binding, cell signaling, differentiation, and epigenetic regulation.
Proliferation, apoptosis, and tumor development in experimental models.
Human studies, study design, and the limits of the available evidence.
Natural killer cell activity and experimental immune responses.
Glucose metabolism, mineral crystallization, and cardiovascular research.
Oxidative stress and neuroprotection in preclinical models.
Studies from the research collection. Publication dates refer to the original papers.
Bacic I, et al. Journal of Experimental & Clinical Cancer Research. 2010;29:12.
Study design Randomized, placebo-controlled pilot study; 14 participants.
The investigators reported differences in quality of life, functional status, and blood-count outcomes during chemotherapy. The small sample limits the conclusions.
Schroterova L, et al. Oncology Reports. 2010;23(3):787-793.
Study design Human colorectal carcinoma cell lines: HT-29, SW-480, and SW-620.
IP6 and inositol were studied individually and in combination. Effects varied with concentration and cell line; inositol enhanced apoptosis-related activity with IP6 in the tested models.
Shamsuddin AM, Ullah A, Chakravarthy AK. Carcinogenesis. 1989;10(8):1461-1463.
Study design Experimental study in CD-1 mice.
An early University of Maryland investigation of inositol and IP6 in cell proliferation and tumor formation. Animal experiments provide biological evidence; they do not establish efficacy in people.
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